PFOA and PFOS are two of the nearly 5,000 individual per- and polyfluoroalkyl substances (PFAS) identified to date. Numerous scientific studies from the last 10 years have shown that exposure to PFAS can lead to adverse human health impacts.
Cardno ChemRisk performed an assessment of the epidemiological and toxicological evidence on the carcinogenic potential of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS).
This work included the integration of key human, animal, and mechanistic studies while considering study quality, the consistency of findings within and across lines of evidence, and species concordance.
The assessment is likely to be extended to reviews of additional endpoints of concern (e.g., developmental toxicity and immunotoxicity).