What is the impact of alcohol-containing e-cigarette use on blood alcohol concentrations?
Our team recently published a study in which a modeling approach was used to determine the blood alcohol concentrations (BACs) of people who used e-cigarettes containing alcohol as an ingredient.
We prepared vaping profiles using a detailed review of the peer-reviewed literature published on the topic of “topography,” or device usage characteristics. We focused the review on subjects who used first-generation “cig-a-likes” and second-generation tank-style e-cigarettes.
Representative topography profiles were used to develop exposure inputs for a previously validated physiologically-based pharmacokinetic (PBPK) model for intermittent inhalation exposures to alcohol. We found the predicted BAC values were over 100 times lower than a commonly accepted lower threshold for physiological impairment (0.01% or 100 mg/L).
The approach – which combined a detailed topography data assessment with a validated PBPK model – is useful for performing screening-level exposure assessments for other chemicals that may be found in e-cigarettes.
Check out our infographic for more details on the study formulation, methods, results, conclusions, and recommendations for future research.
At Cardno ChemRisk, our team of human health risk assessment professionals have conducted research into the toxicology and kinetics of alcohol in the body following inhalation and ingestion.
Our toxicologists and epidemiologists have performed detailed research on the topography of e-cigarette use in various user demographics and in users of various device generations. Reach out to us if your organization would like to learn more about our expertise in toxicological or epidemiological analyses relevant to e-cigarettes, electronic nicotine delivery systems (ENDS), and drug and alcohol pharmacokinetics.
Josh Maskrey, CIH, is a board-certified industrial hygienist whose areas of expertise include quantitative exposure assessment, human health risk assessment, and chemical engineering. He maintains a broad risk assessment practice focused on environmental, health, and safety services.
Sharlee More, PhD, has professional experience in the areas of toxicology and human health risk assessment. She is actively involved in multiple efforts related to understanding the toxicology and potential hazard and risk of various occupational exposures, environmental exposures, as well as exposures associated with medical devices and e-cigarette devices.
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