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Publication reviews cosmetic talc exposure and mesothelioma

Cardno ChemRisk scientists publish a weight of evidence analysis for cosmetic talc and mesothelioma risk.

Cardno ChemRisk scientists, Michael Ierardi, MES, MS; Ania Urban, MPH, PhD, and Gary Marsh, PhD, FACE recently published a quantitative analysis of Sir Bradford Hill’s guidelines for causal inference to assess the overall probability of causality between cosmetic talc exposure and mesothelioma.

Portrait of Ania Urban, Mike Ierardi, and Gary Marsh

The authors specifically integrated and assessed multiple lines of scientific evidence, including epidemiological data (e.g., cohort studies, case-control studies, ecological analyses), animal toxicity studies, industrial hygiene/exposure data, as well as carcinogenicity conclusions of government agencies and international scientific organizations as they relate to the potential relationship between cosmetic talc and mesothelioma. A low probability of causality (1.29%) was calculated, indicating that cosmetic talc is not causally related to the development of mesothelioma.

“Our finding makes an important contribution to the growing body of literature related to the potential human health effects associated with talc exposures and has important implications for occupational health physicians, risk assessors, among others, who are actively engaged in conducting human health risk assessments on this topic.” — Michael Ierardi.

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